Background: Presence of microvascular obstruction (MVO) derived from cardiac magnetic resonance (CMR) imaging is\namong the strongest outcome predictors after ST-segment elevation myocardial infarction (STEMI). We aimed to\ninvestigate the comparative predictive values of different biomarkers for the occurrence of MVO in a large cohort of\nreperfused STEMI patients.\nMethods: This study included 128 STEMI patients. CMR imaging was performed within the first week after infarction to\nassess infarct characteristics, including MVO. Admission and peak concentrations of high-sensitivity cardiac troponin T\n(hs-cTnT), creatine kinase (CK), N-terminal pro-B-type natriuretic peptide (NT-proBNP), high-sensitivity C-reactive protein\n(hs-CRP), lactate dehydrogenase (LDH), aspartate transaminase (AST) and alanine transaminase (ALT) were measured.\nResults: MVO was detected in 69 patients (54%). hs-cTnT, CK, hs-CRP, LDH, AST and ALT peak concentrations showed\nsimilar prognostic value for the prediction of MVO (area under the curve (AUC) = 0.77, 0.77, 0.68, 0.79, 0.78 and 0.73, all\np > 0.05), whereas the prognostic utility of NT-proBNP was weakly lower (AUC = 0.64, p < 0.05). Combination of these\nbiomarkers did not increase predictive utility compared to hs-cTnT alone (p = 0.349).\nConclusions: hs-cTnT, CK, hs-CRP, LDH, AST and ALT peak concentrations provided similar prognostic value for the\nprediction of MVO. The prognostic utility of NT-proBNP was lower. Combining these biomarkers could not further\nimprove predictive utility compared to hs-cTnT alone.
Loading....